7:30 PM. , 2006). com. Vreme 10 dniNeurodegenerative diseases are characterized by the loss of neurons and/or myelin sheath, which deteriorate over time and cause dysfunction. ca Website: Twitter: @TCNLabEosu Kim, Benjamin U. Bussey-Saksida Rodent Touch Screen Chambers. Saksida: A real find! - See 53 traveler reviews, 84 candid photos, and great deals for Saksida at Tripadvisor. Viral Diseases of Wild Fish. Repki so knjiga, ki se jo da tudi poslušati. This process, referred to as adult neurogenesis, produces new neurons. Ivan Bukovec (umetnik) Jože Bunič. While the scope of such reforms is still to be determined, there has been talk in the taxation community of the possibility of a lifetime cap, or a maximum main residence relief per transaction. Change management is a key to successfully. Edition. Infectious diseases are common in the ocean, and here we tabulate 67 examples that can reduce commercial species' growth and survivorship or decrease seafood quality. Prior to joining Stifel FirstEnergy, he spent over 2 years as the Head of Canadian Energy Investment. Ich sorge nicht nur für Ihr Wohlbefinden, sondern auch für einen perfekten Teint. torek. Se desconoce la prevalencia de la infección en casos crónicos. The Touch Screen has been used to develop a wide range of tasks, probing different areas of cognition, most of which are available ready written with programs [email protected] lice (singular: sea louse) are copepods (small crustaceans) of the family Caligidae. Tilka Jamnik, podpredsednica: e-mail: tilka. Gina Gallant, Assistant Professor of Organizational Behaviour, was thrilled. visual effects generalist artist: Light VFX (uncredited) Johnny Guang Yuan He. Purchasing & Supply Chain Excellence. . Kometa C/2022 E3 (ZIF) - Boris Saksida po drugi put. 20320 Abstract The prevailing paradigm in cognitive neuroscience assumes that the brain can be best understood as consisting of modules specialised for different. Facebook gives people the power to. 3760/cma. Meg Saksida BA, FCA, CTA, TEP (af. Both have grown in popularity, with many employers using them to enhance the skills, knowledge and performance of their people around specific skills and goals. The self-ordered spatial working memory tasks is sensitive to lesions of the dentate gyrus and CA3. These impacts seem most problematic in the stressful and crowded conditions of aquaculture, which increasingly dominates seafood. Beside morphological alterations and tissue remodelling within. Introduction Dr. Lisa Saksida. Here we investigate the perception. E-naslov: melita. 7 billion (in 2018/19), it is possible that it may be subject to ‘practical operation’ reforms. They are also recognised as a distinct model of an emergent zoonotic infection with a global distribution. These impacts seem most problemati. Sofia Gonzalez Saksida. Sort by citations Sort by year Sort by title. Saksida. Milan Butina. Lisa M. Mifepristone, also known as RU486, was the result of the biomedical revolution forced by the wave of women´s movements in the 20 th century seeking to control their reproductive life ( Spitz, 2010 ). PETEK: 7. The global population is aging, and in many countries the people over the age of 65 have surpassed the number of children (United Nations Department of Economic and Social Affairs, 2013). Samaha, Anne-Noël Université de Montréal. Maša Salopek, the main pastry chef in Hiša Franko, has. [email protected]: Tau is a microtubule-associated binding protein implicated in neurodegenerative tauopathies, including frontotemporal dementia (FTD) and Alzheimer's disease (AD). Osebe pooblaščene za odločanje v upravnem postopku (28. The increased life expectancy for patients with Down Syndrome (DS) has elicited renewed interest in the factors that may contribute to their characteristic poor linguistic development, overall intellectual disability, and the developmental trajectory associated with long-term cognitive decline in this population (1, 2). Osebna pomoč z elementi socialne aktivacije. Andrej Brumen-Čop. Sales: +386 73 56 93 03. Dr Emanuele Dotto. 5 cm from the floor of the chamber. The higher the level of BDNF, the better the cognitive functioning (Bekinschtein, Oomen, Saksida, & Bussey, 2011; Novkovic, Mittmann, Manahan & Vaughan, 2015). Zalošče 42, 5294 Dornberk t: +386 (0)5 301 88 70 m: +386 (0)31 665 974 anka. Za otroke je urejen manjši bazen, nekaj igral, fitnes na. Amnesia is characterized by a number of memory deficits, including the apparent inability to distinguish between novel and familiar stimuli. E. Adapted from J. See 59 traveler reviews, 91 candid photos, and great deals for Saksida, ranked #1 of 18 specialty lodging in Nova Gorica and rated 4. ORCID provides an identifier for individuals to use with their name as they engage in research, scholarship, and innovation activities. Smo neodvisna neprofitna organizacijaki podpira visoko nadarjene študente in učence. Syaakakisidai tu dah kat malaysia ni kau tak fuck dgn dia ke bro — Busy. stoletja. Ponuja brezplačen brezžični internet ter klimatsko napravo. Several novel hantaviruses with unknown pathogenic potential have been. Syaakakisidai tu dah kat malaysia ni kau tak fuck dgn dia ke bro — Busy body bebenor kamu semua ji. mag. Saksida Neuroscience Graduate Program, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada Oren Princz-Lebel Abstract. 00 - 15. 肾综合征出血热 (hemorrhagic fever with renal. Each neuron makes about 1,000 connections to other neurons. Dragica Haramija in dr. Tel: 031 390 265 (službena mobilna številka) E-naslov: helena. ac. Zdaj z novo knjigo in albumom Repki vabita v svet otroške poezije, iskrivega repa in hudomušnih ilustracij otroke in njihove. The Thomistic Institute in London presents a lecture by Dr. Memory loss is a usual consequence of ageing and aged mice show progressive deficits in memory tasks. Nastanitvene enote nudijo prostor za sedenje, nekatere pa tudi teraso in/ali balkon. The prevalence of infection in chronic cases remains unknown. Dr Josephine Evans. MRC and Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom. Veća : Još neke fotografije Borisa Sakside: Kometa C/2022 E3 (ZIF) pored Marsa - Boris Saksida . The Hiša Franko restaurant near Kobarid can boast two exceptional women whose mastery as chefs is recognised by gastronomy experts around the world. si. outcomes, such as retention rates (Saksida, Alfes, & Shantz, 2016), as well as organizational outcomes, such as client satisfaction ratings (Rogers, Jiang, Rogers, & Intindola, 2016). . Sašo has 1 job listed on their profile. We found heterozygosity for the TLR3 p. 中华传染病杂志, 2021,39 (5) : 257-265. En casos crónicos, las pérdidas se prolongan y se pueden observar peces en diversas etapas de la enfermedad en el estanque. These relations have been investigated using several different visual attention paradigms and with variable controls for other competing reading-related processes. Now $124 (Was $̶1̶5̶9̶) on Tripadvisor: Saksida, Nova Gorica. Professor and Canada Research Chair in Translational Cognitive. bwinters@uoguelph. SAKSIDA $124 ($̶1̶5̶9̶) - Prices & Campground Reviews - Nova Gorica, Slovenia. Beside morphological alterations and tissue remodelling within. . This plasmid is available through Addgene. This circuit involves the nucleus reuniens (NR), a thalamic nucleus of largely unknown function. How ventral visual stream (VVS) regions represent subjectively perceived object characteristics remains poorly understood. Infectious diseases are common in the ocean, and here we tabulate 67 examples that can reduce commercial species' growth and survivorship or decrease seafood quality. V sklopu nastanitve je na voljo brezplačno zasebno parkirišče. Boris Saksida. Bacteriophages (or phages), the most abundant viral entity of the planet, are omni-present in all the ecosystems. Delpinova ulica 18b, 5000 Nova Gorica Telefon: 05 330 29 00; Fax: 05 330 29 13; E-pošta: gpcsd. We are also part of the Krog Umetnosti-Art Circle project, which brings together art and wine in the. Very recently, several novel hantaviruses with unknown pathogenic potential have been identified in a variety of. Campden behavioral products include standard and modular operant systems, cognitive testing, sleep deprivation, and many others. Interleukin 17A is the signature cytokine of a subset of CD4+ helper T cells known as Th17 cells, and the IL-17 cytokine family contains six cytokines and five receptors. Get a D&B Hoovers Free Trial. The typical sign of kidney injury is loss of renal function, as indicated by a reduced estimated glomerular filtration rate (eGFR). sreda. Kanalıma hoşgeldiniz. Recently, several studies have. The ability to directly measure acetylcholine (ACh) release is an essential first step towards understanding its physiological function. Igor SaksidaNa Pedagoški fakulteti izvajamo študijske programe na treh stopnjah: dodiplomske študijske programe, eno in dvoletne magistrske študijske programe ter doktorski študij. odstavkom 21. Latin America. Mar AC, Gamallo B, Oomen CA, Saksida LM, Bussey TJ. We completed exome sequencing of seven adult patients with encephalitis or encephalomyelitis during acute PUUV infection. Maje Zaman Groff, in skladno s 1. Research Article Ferroptosis as a Novel Determinant of β-Cell Death in Diabetic Conditions Ana Stancic ,1 Tamara Saksida ,2 Milica Markelic ,3 Milica Vucetic ,4 Ilijana Grigorov ,1 Vesna Martinovic ,1 Dragica Gajic ,2 Andjelija Ivanovic ,1 Ksenija Velickovic ,3 Nevena Savic ,1 and Vesna Otasevic 1 1Department of Molecular Biology, Institute for Biological. ORCID record for Ivana Nikolić. 10 Jul 2009. Therefore, we investigated the potential of diabetes-mimicking factors: high glucose (HG), proinflammatory cytokines, hydrogen peroxide (H 2 ), or. com! Na voljo so številni mešalci različnih vrst. Inhibition is the ability to suppress a behavior or action when it is inappropriate — such as calling out loudly when one is in an audience or classroom. Konjak; Žganje; Pridelava vin Gojitvena oblika je enojni »Guyot«, gostota sajenja 4000-6000 trsov na hektar. Uros Saksida. nimac@gov. All issues. andrej@siol. E-naslov: anamarija. 1,682,380 likes · 17,495 talking about this. He facilitates a number of experiments on the effects of isolation, light deprivation, and extreme temperatures on the human body and mind. The best example of autoshaping comes from work done with pigeons: if a lighted key always turns on. Join to view full profile. Yulong Li's lab contains the insert GPCR activation based ACh sensor GRAB-ACh3. Pancar, saksılarda rahatlıkla yetişebilir. Slovenijo krasi čudovita narava, ki ima v vsakem delčku zelene dežele drugačen značaj. She called an ambulance, conducted a breathing test on her mum and followed the operator’s instructions until the ambulance arrived. 1 zákona č. As of April 1, 2017. si. Med letoma 2018 in 2022 je bil tudi predsednik te institucije, pred tem pa tudi dvakratni minister za kmetijstvo, gozdarstvo in prehrano. He will report to Steve Trauber and Michael Jamieson, co-heads of global energy at Citi, as well as John. He is the Principal Investigator for the ‘Conceptual Clarity Concerning Human Nature’ project funded by the Templeton World Charity Foundation. Prilagoditve pri ocenjevanju učenca s posebnimi potrebami pri predmetu šport. & Saksida, 1997). Space and Time 283. However, it remains unknown whether and where the visual and abstract conceptual features that define an object concept are integrated. By attending the. Our programs offer personalized learning, small class sizes, great access to professors, and career-focused outcomes. See 59 traveler reviews, 91. The role of glucocorticoids in glucose intolerance development in MIF-deficient mice. Menu. Bu gübreleri nasıl hazırladığımı buradan seyredebilirsiniz. dobnikar@gov. Valuable research and technology reports. Objectives: This article provides a review of the touchscreen battery of tasks for rats and mice for assessing cognitive domains relevant to schizophrenia and highlights validation data presented in several primary articles in this issue and elsewhere. Neurogenesis occurs throughout life in the hippocampus (blue), an area of the brain involved in learning and memory. This system was significantly cheaper than commercial alternatives, at approximately €3,000. Introduction. Fakat aslında bunlar arasına. Chambers for Electrophysiology. Na Filozofski fakulteti je diplomiral leta 1990 ( slovenski jezik s književnostjo, primerjalna književnost) in za svoje delo prejel študentsko Prešernovo nagrado. If you have a speech or hearing impairment, you can call us using the Relay Service by dialling 18001 followed by 0345 702 3344. Phone: +49 711 501-0 Contact: © by MAHLE GmbH, Stuttgart 2023Boyer D Winters 1 , Lisa M Saksida, Timothy J Bussey. Keywords: alpha-synuclein, Parkinson’s disease, mouse model, neuroimaging, cognition, prion, prion-like, Lewy-body. Ker njihovo delo vključuje klesanje kamenja je v dnevnih urah možen hrup. . This drug is a synthetic hormone with antiprogestogen receptor blocker and glucocorticoid receptor (GR) antagonism activity. eAsistent - rešitev za srednje, osnovne in višje šole. In parallel there is a growing realization that high-throughput measures of mouse behavior widely used in these fields are often of. The advantages of the touchscreen platform have been discussed in detail elsewhere (see 1-3). , 2007, Saksida and Bussey, 2010). Author. M. oktobrom gostili kiparje. To activate this feature, instead of the line: audio=r. We have previously shown that the CE used in this study activated macrophages and stimulated effector T cell differentiation in vitro. Urša Škornik. RT @syaakakisidai: So guys i nak korang berhati hati dengan acc ni @bryy_leee !!! Sebab jantan bodoh bebal ni dia ada acc DS then dia expose i dekat FB tanpa dia sedar yang dia TERLEBIH BODOH sebab expose diri sendiri yang ada acc DS 😂😂 . Verbal working memory was tested with the WISC digit span subtest (Wechsler, 2005). Varstvo odraslih (starejši od 65 let) Družinski pomočnik (za osebe starejše od 65 let) Maja Jelenc. CKD is defined as a clinical condition where eGFR persists abnormally (≤60 ml/min/1. Before coming to Oxford, De Haan was a. Facebook gives people the power to. Veća. amb 6 azarija/bokal izm. As main residence relief is a relief worth £26. , Tanaka, K. Studies show that the speech envelope is important for speech perception in adults and infants. Abstract. CMU School of Computer ScienceOBVESTILO Naše posestvo je del projekta ART CIRCLE, v sklopu katerega v kampu vsako leto gostimo akademske umetnike. com Zgornje Škofije 97 6281 Škofije Št. Now $124 (Was $̶1̶5̶9̶) on Tripadvisor: Saksida, Nova Gorica. 1. The judge also ordered that. Tim Bussey and Lisa Saksida have established a series of targeted cognitive tests for animals, administered via touchscreen within a custom environment known as the “Bussey-Saksida touchscreen chamber”. The Bussey-Saksida Chamber has always featured a unique trapezoidal wall shape in order to focus the animal's attention and. See new Tweets Sea louse. cn311365-20210224-00067. Language Processing. Abstract. . This analytic review focuses on theory and research on volunteerism. An imbalance of the intestinal bacteria representation (dysbiosis) could lead to different diseases, ranging from obesity and diabetes, to neurological disorders including Alzheimer’s disease (AD). Experienced researcher focused on connection between gut immune system and distant sites, like brain in Alzheimer's & Parkinson's disease, like pancreas in diabetes. Fearful anticipation of imminent pain could play a role in this. 3604 [email protected]@gov. J. E-naslov: ursa. Program Materinski dom Ljubljana. amb 8 djuriŠiČ - 1. Blake Jelley and Tina Saksida, UPEI (last revised 2021-10-20). 00. Blake Jelley and Tina Saksida, UPEI (last revised 2021-10-20). Od 26. This factsheet offers a definition of coaching and mentoring, distinguishing between the two and emphasising. 8. Stimulus delivery/detection and operant box input/outputs were controlled with custom written software (“MouseCat”, L. Contact Sašo directly. Aktive Nährstoffkosmetik, Natürlich, Frei. cg artist: Light Björn Gottwald. He received his PhD through an industrial scholarship at the University of Sussex and Eli Lilly Ltd. This factsheet offers a definition of coaching and mentoring, distinguishing between the two and emphasising. Timothy J. Smaill, and Heba Lakany. Let’s talk science, part 4: sex. si. Both logical reasoning and emotional (affective) decision. Worksheets - handouts. On the strength of 10 years of feedback and development, the system is even more flexible and with more features. Excludes international. Department of Psychology, University of Cambridge, Cambridge, UK. Data from 534 volunteers of an international aid and development agency in the United Kingdom revealed a positive relationship between prosocial values and time spent volunteering. 这些病原体可导致两种重症急性发热性疾病：. Join Facebook to connect with Erika Saksida and others you may know. Spletna aplikacija UJPnet. In adult population. Bu hizmet sayesinde uzaklardaki sevdiklerinize bile kolayca çiçek göndererek onları mutlu edebilirsiniz. 汉坦病毒属于布尼亚病毒科的一个包膜病毒属，即汉坦病毒属 ( Orthohantavirus )。. 83604 e. ČETRTEK: 7. Evelyn was just nine. afectadas de entre el 20 y el 94% (Saksida, 2006). p, Zalošče 12 a, 5294 Dornberk, SI79829716: namestitve in gostinstvo Ingrid Saksida, Zalošče 12a, 5294 Dornberk, KGM MID 100927208: pridelava in prodaja vina TDP-43 Q331K causes behavioural phenotypes and disproportionately affects male mice. 1002/hipo. Tel: 04/2568-749. cucnik@gov. IntroductionA broad community of researchers from non-behavioral backgrounds are now assessing behavioral outcomes in fields as diverse as gene mapping, mutagenesis screening, and drug screening [8], [42]. Neposredno izvajanje skrbniških nalog. We chose to introduce the n. 2023 do 31. T: 05 3350353. The limited available dataTEAM delivers asset-centric solutions across a wide range of industries and applications. The green area is Wernicke’s area, which is responsible for understanding others’ speech. We host artists who create their art in the inspiring surroundings of the vineyards. In the case at hand, the corpora consisted of transcriptions of the. See the complete profile on LinkedIn and discover Sašo’s connections and jobs at similar companies. adım: Avokadonun içinden çekirdeğini dikkatli bir şekilde çıkarın. Background. matte painter: Pixomondo (uncredited)Introduction. How neurogenesis contributes to hippocampal function is largely unknown. si. experiments. Thomistic Institute - London. Behavioral data consists of mouse position data taken from the. si je Izobraževalna gradiva za slovenščino v osnovni šoli od 6. p. A black Perspex “mask” with task-specific response windows was placed over the screen, to reduce unintended responding by tail or other body parts. Obveščevalec - obveščanje staršev o izostankih, ocenah, napovedanih ocenjevanjih znanja, predelani učni snovi. Ob njej so odraščale generacije, zdaj smo jo približali otrokom 21. marusic@gov. This year we will be hosting sculptors between the 4th and 13thPubMedA lifespan trajectory of synapse protein lifetime. . Bus 2880 (Fall 2021) – Case Competition COMMUNICATING PAY CUTS IN GLENWOOD Case prepared by R. 83604/ 519. Thanks also to Howie Schrobe, Trevor Darrell, Peter Szolovitz and Mildred Dressellhaus for being on exam boards for me. The impaired function of the intestinal barrier and dysbiosis precede the development of T1D both in humans and mice. Pri Kovačniku je vse izdelano do popolnosti – od dekoracije, ki vas pričaka že ob vhodu in je prilagojena letnemu času, krasne okolice domačije, igral za otoke, do več kot odlične hrane izpod rok tete Barbke. Thursday, June 1. Oproštaj od komete C2020 F3 Neowise - Boris Saksida. Steurer, Aust, and Huber ( 2012) demonstrated a low-cost touchscreen operant chamber that could be used by a variety of species, such as pigeons, tortoise and dogs. in 3. Abstract. Thereafter, mice were divided into sedentary ( n = 4) and runner ( n = 4) groups, injected with BrdU over 5 days, and trained for an additional 10 days on the same task (block 2). Saksida) written in Visual Basic 6 (Microsoft, Redmond, WA, USA). Mar. Dr. visual effects generalist artist: Light VFX (uncredited) Johnny Guang Yuan He. novembra 2023, organizirali dogodek »Inovacije in pika« z namenom predstavljanja pomena inovacij za raziskovanje ter razvoj in izpostavljanja vprašanj na kakšen način inovativno ter primerno. , 1995) and in songbird vocalization (Doya & Sejnowski, 1995). Karlsson, RM. His work has focused on the use. 0 from Dr. The software is used to run the task and record the behavioral activity of the mouse. 4. Read More View Contact Info for Free Sonja Saksida's Phone Number and Email Last Update 11/12/2023 7:38 AM Email s-) * Sign up. All testing took place in standard mouse Bussey-Saksida touchscreen chambers (Campden Instruments Ltd, Loughborough, UK), described in detail elsewhere [28, see Supplementary Materials and Methods]. Uradna spletna stran Centra za socialno delo GorenjskaAbstract Visual arts media in pre-school and early school years and development of children’s drawing are well researched. Request a callback. Binella Medical Beauty unterstützt mich dabei mit besten Eigenschaften. Saksida says a rough guess is the human brain contains 90 to 100 billion nerve cells or neurons. čl. This method is non-aversive and relies on reward to motivate animals, and once basic learning has been acquired, tasks can then be scaled. com Strokovno sodelovanje: Dr. Movies. 1. , the. Having spent many years as an expat herself, Meg’s special interest is capital taxes with a focus on the issues surrounding international clients here, and British expats abroad. TV Shows. How VVS representations capture fine-grained visual similarities between objects that observers subjectively perceive has received limited examination so far. Rev. The signs of freedom of expression and imagination, intuitiveness and. Ker njihovo delo vključuje klesanje Both tasks were conducted using the automated Bussey–Saksida touchscreen system for mice (model 80614; Lafayette Instrument, Lafayette, Indiana) and the data collected using ABET II Touch software Version 2. Avion i kometa C2020 F3 Neowise - Boris Saksida. Robarts Research Institute, Rm 3228, Western University, 1151 Richmond St N, London, ON, N6A 5B7. Aerobic exercise like running can improve cognitive function in people, and one of the ways it may do this is by enhancing neurogenesis. Saksida) and visible through the windows (1 stimulus/window)[email protected]. Još jedan avion i kometa C2020 F3 Neowise - Boris Saksida. Se desconoce la prevalencia de la infección en casos crónicos. Cited by. Njena sestava izžareva radost radovednega otroka, ki se sprašuje: Kaj je kaj?Plasmid pAAV-hSyn-GRAB_ACh3. Spoznala sta se prek spleta, druži pa ju velika ljubezen do hribov. Interested in modulating gut immunity to improve health. Greg Saksida joined Stifel FirstEnergy in 2022 as Managing Director, Investment Banking covering the Canadian and international energy sectors. časopisu, se v poševnem tisku piše ime revije in letnik. Add to Quote. Oddelek za infekcijske bolezni in vročinska stanja. Strong information technology professional with a BCompSci focused in. Dr Martin Gallauer. Avtor spremne besede dr. FULL STORY. Listemizde toplamda 17 farklı meyve ve sebze var. , 2016; White et al. In this context, one of the key challenges for Bangladesh Aquaculture is to maintain sustainable. Unser Service Das Landgut Saksida im Vipava-Tal Reservierung Reservierung NOTICE Our estate is a part of ART CIRCLE and every year we host academic artists at the campsite. Strokovno se ukvarja predvsem s slovensko mladinsko književnostjo . Therefore, several studies have reported and suggested that using different bacterial and viral vaccinations in animal populations could result in. Prvi zmenek je sicer potekal na kavi v enem od ljubljanskih lokalov, a že na drugi zmenek je Mitja Mašo peljal v Osp na naravno plezališče, Maša pa nato njega na tretji zmenek v hribe. Sort. 鼻周皮层受损可影响视觉识别. IZJAVA . All tasks in the touchscreen battery. Prenesite vse 1. 1002/HRM. Like DNMTP, the new TUNL task uses only two locations in any given trial, but uses multiple. Contributor. Bojan Križaj. How does the brain achieve complex cognitive tasks like learning, memory and attention? Lisa Saksida, PhD, studies. , 2005) and a spoonerism test (Bosse and Valdois, 2009). Osebna pomoč z elementi socialne aktivacije. Since people are living longer, there is an increase in the prevalence of diseases associated with aging (Jaul and Barron, 2017), such as. Če želite v terminuAbstract. Reviewed 1 May 2023. com! Всички онлайн филми са вградени от други сайтове, сайта не съдържа никакви аудио или видео файлове Filmi2k. Zaposleni. Call us at +0345 702 3344 *. Sugar Land, Texas 77478 UNITED STATES Phone: 800-662-8326Saxenda ® (liraglutide) injection 3 mg is an injectable prescription medicine used for adults with excess weight (BMI ≥27) who also have weight-related medical problems or obesity (BMI ≥30), and children aged 12-17 years with a body weight above 132 pounds (60 kg) and obesity to help them lose weight and keep the weight off.